• Associations between Serial Intravitreal Injections and Dry Eye 

      Malmin, Agni; Thomseth, Vilde Marie; Førland, Per Tore; Khan, Ayyad Ahmad Zartasht; Hetland, Hanne Brit; Chen, Xiangjun; Haugen, Inga Britt Kjellevold; Utheim, Tor Paaske; Forsaa, Vegard Asgeir (Journal article; Peer reviewed, 2023)
      Purpose To investigate the effects of serial intravitreal injections (IVIs) on the ocular surface and meibomian glands (MGs) in patients treated with anti-vascular endothelial growth factor (anti-VEGF) for neovascular ...
    • Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future 

      Fineide, Fredrik; Magnø, Morten Schjerven; Khan, Ayyad Ahmad Zartasht; Chen, Xiangjun; Vehof, Jelle; Utheim, Tor Paaske (Journal article; Peer reviewed, 2023)
      Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. It is considered an inflammatory disease and the most common cause is meibomian gland dysfunction. ...
    • Predicting an unstable tear film through artificial intelligence 

      Fineide, Fredrik; Storås, Andrea; Chen, Xiangjun; Magnø, Morten Schjerven; Yazidi, Anis; Riegler, Michael; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. Establishing a diagnosis can be time-consuming, resource demanding and unpleasant for the patient. ...
    • Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers 

      Aqrawi, Lara Adnan; Galtung, Hilde; Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Skarstein, Kathrine; Jensen, Janicke Liaaen (Peer reviewed; Journal article, 2019-07-31)
      Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ...
    • Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation 

      Stojanovic, Aleksandar; Chen, Xiangjun; Jin, Nan; Zhang, Ting; Stojanovic, Filip; Ræder, Sten; Utheim, Tor Paaske (Journal article; Peer reviewed, 2012)
      Purpose: To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods: This non-randomized retrospective ...
    • Seasonal variations in presenting symptoms and signs of dry eye disease in Norway 

      Eidet, Jon Roger; Chen, Xiangjun; Ræder, Sten; Badian, Reza; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      The study investigated the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway. 652 consecutive DED patients examined between August 2012 and May 2015 in Oslo, Norway, were included. ...
    • Tear production levels and dry eye disease severity in a large Norwegian cohort 

      Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann; Utheim, Tor Paaske (Peer reviewed; Journal article, 2018)
      Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ...